Quinta das Amendoeiras has been in the Negreiros family since the 1940s, when it was bought by Joaquim Trigo de Negreiros, father of the current owner. This acquisition marked the return of the family to the Douro, from where they had parted during the phylloxera plague at the end of the 19th century.

No one knows precisely when the winery was built. What is known is that the winery produced Port wine which was sold to Cockburn's. When this company acquired the neighbouring Quinta dos Canais and built there a state-of-the-art winery, Quinta das Amendoeiras dismantled its own winery and started selling its in-natura grapes to Cockburn's to whom it also passed, according to a loan for use agreement, all the oak casks that for decades had been used for its Port.